Dihydroartemisinin enhances cell apoptosis in diffuse large B cell lymphoma by inhibiting the STAT3 activity

Background: Dihydroartemisinin (DHA) is reported to be a potential anticancer agent, and the mechanisms underlying effects of DHA on diffuse large B cell lymphoma however are still obscure. This study aimed assess antitumor effect cells determine DHA-induced apoptosis. Methods: Here, Cell Counting Kit 8 assay was conducted proliferation. We performed Annexin V-FITC/propidium iodide staining, real-time polymerase chain reaction, western blot analysis analyze apoptosis molecular mechanisms. Results: The results showed that substantially suppressed proliferation induced in vitro in time- concentration-dependent fashion. Moreover, STAT3 activity could inhibited after stimulation with DHA. Conclusion: These imply anti-tumoral may increase via signaling pathway. In addition, might an effective drug for therapy.